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Treatment is combined with a suitable diet and balanced exercise. Glimepiride increases the amount of insulin released from the pancreas and helps your body to use insulin more efficiently. <br /> <h3><u>What should I tell my health care provider before I take this medicine?</u></h3><br /> <p><h4> They need to know if you have any of these conditions:</h4></p> • diabetic ketoacidosis<br /> • kidney disease<br /> • liver disease<br /> • major surgery<br /> • severe infection or injury<br /> • thyroid disease<br /> • an unusual or allergic reaction to glimepiride, sulfonamides, other medicines, foods, dyes, or preservatives<br /> • pregnancy or recent attempts to get pregnant<br /> • breast-feeding<br /> <h3><u>How should I take this medicine?</u></h3><br /> Take glimepiride tablets by mouth. Follow the directions on the prescription label. Swallow the tablets with a drink of water. Take your dose at the same time each day, with breakfast or your first large meal; do not take more often than directed.<br /> <br /> Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed.<br /> <br /> Elderly patients over 65 years old can have a stronger reaction and need a smaller dose.<br /> <h3><u>What if I miss a dose?</u></h3><br /> If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.<br /> <u>What drug(s) may interact with glimepiride?<br /> </u>• bosentan<br /> • medicines for fungal or yeast infections (examples: fluconazole, itraconazole, voriconazole)<br /> • rifampin<br /> • warfarin<br /> <br /> <p><h4> Many medications may cause changes (increase or decrease) in blood sugar, these include:</h4></p> • alcohol containing beverages<br /> • aspirin and aspirin-like drugs<br /> • beta-blockers, often used for high blood pressure or heart problems (examples include atenolol, metoprolol, propranolol)<br /> • chromium<br /> • female hormones, such as estrogens or progestins, birth control pills<br /> • isoniazid<br /> • male hormones or anabolic steroids<br /> • medications for weight loss<br /> • medicines for allergies, asthma, cold, or cough<br /> • niacin<br /> • pentamidine<br /> • phenytoin<br /> • quinolone antibiotics (examples: ciprofloxacin, levofloxacin, ofloxacin)<br /> • some herbal dietary supplements<br /> • steroid medicines such as prednisone or cortisone<br /> • thyroid hormones<br /> • water pills (diuretics)<br /> <br /> Tell your prescriber or health care professional: about all other medicines you are taking including nonprescription medicines; if you are a frequent user of drinks with caffeine or alcohol; if you smoke; or if you use illegal drugs. These can affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.<br /> <h3><u>What side effects might I notice from taking glimepiride?</u></h3><br /> <p><h4> Side effects that you should report to your prescriber or health care professional as soon as possible:</h4></p> • anxiety or nervousness, confusion, difficulty concentrating<br /> • blurred vision<br /> • breathing difficulties or excessive phlegm<br /> • cold sweats, increased sweating<br /> • cool, pale skin<br /> • coughing up blood<br /> • dark yellow or brown urine<br /> • dizziness, drowsiness<br /> • excessive hunger<br /> • fast heartbeat, palpitations, chest pain<br /> • fever, chills, sore throat<br /> • seizures (convulsions)<br /> • tremor or shakiness<br /> • unusual bleeding or bruising<br /> • unusual tiredness or weakness<br /> <br /> <p><h4> Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):</h4></p> • diarrhea<br /> • headache<br /> • heartburn, stomach discomfort<br /> • increased sensitivity to the sun<br /> • nausea, vomiting<br /> • skin rash, redness, swelling, or itching.<br /> <h3><u>What should I watch for while taking glimepiride?</u></h3><br /> Visit your prescriber or health care professional for regular checks on your progress. 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